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When the sun rises, melatonin secretion is inhibited, and the brain's awake afteronon. In fact, sleep disturbances, both sleeping too much and too little, are one of the key symptoms of depression and other mood disorders. You probably have a pretty good sense of your body's natural rhythms intuitively.

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Experiments in fruit flies which may seem a far cry from humans, but actually serve as excellent models in biological clock studies show that degeneration lookingg the brain occurs much more rapidly when there are problems in the functioning of a key clock gene, and the lifespans of the flies are ificantly shortened. Babies who are given vaccines in the afternoon -- and who sleep more right after -- have better immune responses to the innoculations.

But keeping your schedule on track as much as possible is probably the best advice. The reason for this has recently become clear: A genetic factor involved in the rhythm of the brain's clock also controls the electrical activity in the heart. In fact, jet lag can be considered one type of circadian rhythm disorder.

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Since the biological clock is, in fact, a biological entity, things can go wrong with it that may have less to do with lifestyle or the environment, and more to do with the mechanisms of the clock itself. Although there are certain areas of the body, like the heart, that are able to govern their own function to some degree, there is strong evidence that the body clock plays a major role in controlling many of these fluctuations such as in blood sugar over the hour period.

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Animals who are given vaccines at specific times of the day, when certain proteins that sense bacterial invaders are highest, have a much stronger immune response, even weeks later. Compounds that encourage the inflammatory response rise at night, which is why fevers tend to spike thenand those that inhibit it rise during the day. And when people aftrnoon animals lack the genes that help control the clock's cycle, their sleep-wake cycles can stray even further, or be absent completely.

afternokn It's not just in the lab that these effects are seen. Practice good sleep hygiene, and stick to a sleep schedule that works well for your body to keep the system in its natural rhythm. The Rhythms of the Heart The heart is one organ that, although it can keep time by itself to some degree, relies on the brain's biological clock for cues.

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Mice who are bred to lack this factor -- Kruppel-like factor 15 KLF15 -- or have too much of it, have many more heart problems than normal mice. When humans are allowed to run off their body's clock apart from input from the sun, by being kept in continuous darkness, the body's daily cycle tends to lengthen to about 25 hours.

Shift Work Shift work is another example of how we can get ourselves off-cycle, and this too can develop into a circadian rhythm disorder over the long term. Sometimes it's other tlmer, like genes or biology that play a role. It's not been clear exactly why this connection exists, but weight gain or metabolic changes may be involved.

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Whet Moser It turns out that the same genes and biological factors that govern our internal clock are also involved in how other body systems operate -- and break down. Sometimes the clock can get unset -- as with the changes associated with daylight savings time, air travel, or shift work -- and there's only so much we can do until our body and aftdrnoon clock are in equilibrium again.

What time of day did the crucifixion happen?

For years doctors and researchers have noticed that heart problems like fatal arrhythmias are more likely to occur at certain times of the day, both in the early morning and to a lesser degree, in the evening hours. Taking blood pressure medication in the evening seems to improve its effectiveness because it works with the body's circadian noe.

When night falls and there is less light input to the SCN, the production of melatonin, the hormone responsible for making us feel sleepy, goes up. It's likely that the same effect is true in adults, since our immune systems fluctuate in similar ways. It can be hard to determine whether a afrernoon clock le to health problems, or whether it's the other way around.

People who work the night shift not only have a hard time with their sleep patterns feeling sleepy at work or experiencing insomnia during afetrnoon daybut other systems in their bodies can also feel the effects -- and they can be chronic.

Why the biological clock becomes disrupted in certain people, or naturally with age, is not completely clear, but some have recently suggested that it could in part have to do with the aging of the eyes. This rimer enables the SCN to receive the cues it needs from light in the environment to help it keep time.

When melatonin receptor genes have mutations that damage the connection between the biological clock and insulin release people have a ificantly itmer risk of developing diabetes. Avoid disruptions to your eat-sleep cycles.

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In fact, keeping your body's daily cycle on an even keel may be one of the best things you can do onee your overall health. This is likely because the body is better at fighting infection while it is at rest, and energy can be poured into the effort, rather than into other functions.

People's serotonin levels increase during the part of the day when there is more light available. The same is very likely true obe humans. When jet lag sets in, we feel disoriented, foggy, and sleepy at the wrong times of day because, after changing time zones, our body clock tells us it's one time and the outside environment tells us it's another.

This can happen for different reasons, and we're just starting to timre them in greater detail.

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Natural changes in the lens and even the development of cataracts let less light into the eye and, therefore, the brain; and this can affect biological rhythms. When mice were exposed to a bacterial infection, the severity of their infection reflected the time of day they were infected.

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Turning in a little earlier, cutting back on caffeine late in the day, and saving that last bit of work for the morning rather than staying late up to finish it, can make a big difference in how your internal clock functions and in how you feel. Researchers are finding that disrupted daily rhythms can be good predictors for the development of mild cognitive impairment that comes with age, and even for dementia. But genes also influence the body's clock and circadian rhythms.

We're beginning to understand more about how the clock interacts with and helps govern the function of other systems and affects our overall health. When it's dark, more melatonin is secreted, which als the brain to go into sleep mode. To stay on the hour cycle, the brain needs the input of sunlight through the eyes to reset itself each day. People with mood disorders like depression, bipolar disorder, and seasonal affective disorder SAD have altered circadian rhythms. The chemicals involved in immune system function afhernoon vary.

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Body rhythms don't just enhance vaccines' ability to provide immunity; they can affect the body's ability to battle infection on its own. For example, the hormones responsible for hunger and metabolism rise and fall over the course of the day.

There are many other reasons our bodies' clocks can go out of sync, which probably involve a combination of genetic predisposition and lifestyle choices, such as alcohol consumption. Sometimes we do things ourselves that disrupt our normal rhythms, like flying to a distant time zone.


Understanding this clock-heart connection could help experts de drugs to reduce the risk of heart problems in people by stabilizing the levels of these compounds. Knowing more about how the clock is related to cognitive function and decline could help experts predict -- and perhaps one day prevent -- it from occurring in humans as well. These phenomena underline how particular behaviors or lifestyles can affect the body's clock, but there are other factors at play, like genetics and body chemistry.

Immunity and Vaccinations Most of us have experienced being more susceptible to getting sick when sleep-deprived. The reason for this appears to be that certain chemicals responsible for immune function, like cytokines, wax and wane throughout the day and sleep deprivation deprives us of their best effects. Rhythm and Moods Our internal clocks also have a hand in whether we feel up or down emotionally.